AST-487 (NVP-AST487)
Product Specifications
CAS Number
630124-46-8
Target
FLT3
Applications
Protein Tyrosine Kinase
Smiles
CCN1CCN (CC1) CC2=C (C=C (C=C2) NC (=O) NC3=CC=C (C=C3) OC4=NC=NC (=C4) NC) C (F) (F) F
Molecular Formula
C26H30F3N7O2
Additionnal Information
AST-487 (NVP-AST487), a N, N'-diphenyl urea, is an ATP competitive inhibitor of Flt3 with ki of 0.12 μM.Besides FLT3, AST487 also inhibits RET, KDR, c-KIT, and c-ABL kinase with IC50 values below 1 μM.
Storage Conditions
3 years -20°C powder
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