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APY29

Product Specifications

CAS Number

1216665-49-4

Target

IRE1

Applications

ER stress & UPR

Smiles

C1CC1C2=CC (=NN2) NC3=NC (=NC=C3) NC4=CC5=C (C=C4) N=CN5

Molecular Formula

C17H16N8

Additionnal Information

APY29 is a type I kinase inhibitor of IRE1α that binds to the ATP-binding site on IRE1α and inhibits its autophosphorylation (IC50 = 280 nM) and enhances its RNase function (EC50 = 460 nM) .

Storage Conditions

3 years -20°C powder

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