Altiratinib
Product Specifications
CAS Number
1345847-93-9
Synonyms
DCC-2701
Target
Trk receptor
Applications
Protein Tyrosine Kinase
Smiles
C1CC1C (=O) NC2=NC=CC (=C2) OC3=C (C=C (C (=C3) F) NC (=O) C4 (CC4) C (=O) NC5=CC=C (C=C5) F) F
Molecular Formula
C26H21F3N4O4
Additionnal Information
Altiratinib (DCC-2701) is a potent single-digit nanomolar inhibitor of TRK, Met (c-Met), TIE2, and VEGFR2 kinases with IC50 vaules of 0.9 nM, 4.6 nM, and 0.8 nM for TRKA, B, and C, respectively. It inhibits Met (c-Met) and Met (c-Met) mutant with IC50 values in the range of 0.3-6 nM.
Storage Conditions
3 years -20°C powder
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