MPP+ iodide

Product Specifications

CAS Number

36913-39-0

Synonyms

N-Methyl-4-Phenylpyridinium Iodide

Target

Autophagy

Applications

Autophagy

Smiles

[I-].C[N+]1=CC=C (C=C1) C2=CC=CC=C2

Molecular Formula

C12H12IN

Additionnal Information

MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide), the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces autophagic cell death in SH-SY5Y cells. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons.