ICCB-19 hydrochloride

Product Specifications

CAS Number

1803605-68-6

Target

RIP kinase

Applications

Apoptosis

Smiles

Cl.O=C (CSC1=NCCN1) NC2CCCCCC2

Molecular Formula

C12H22ClN3OS

Additionnal Information

ICCB-19 hydrochloride is an inhibitor of TNFRSF1A Associated Via Death Domain (TRADD) with IC50 of 1.12 μM and 2.01 μM for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs, respectively. ICCB-19 indirectly inhibits Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) . ICCB-19 effectively induces autophagy.