ICCB-19 hydrochloride
Product Specifications
CAS Number
1803605-68-6
Target
RIP kinase
Applications
Apoptosis
Smiles
Cl.O=C (CSC1=NCCN1) NC2CCCCCC2
Molecular Formula
C12H22ClN3OS
Additionnal Information
ICCB-19 hydrochloride is an inhibitor of TNFRSF1A Associated Via Death Domain (TRADD) with IC50 of 1.12 μM and 2.01 μM for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs, respectively. ICCB-19 indirectly inhibits Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) . ICCB-19 effectively induces autophagy.
Storage Conditions
3 years -20°C powder
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