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[Lys8, Lys9]-Neurotensin (8-13)

Selected Variant

HY-P2544-01

Size: 5 mg

[Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with Ki values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively[1].

Product Specifications

CAS Number

139026-64-5

Product Name Alternative

JMV438

UNSPSC

12352209

Target

Neurotensin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lys8-lys9-neurotensin-8-13.html

Purity

99.98

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

CC(C)C[C@@H](C(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC1=CC=C(O)C=C1)NC([C@H]2N(C([C@H](CCCCN)NC([C@H](CCCCN)N)=O)=O)CCC2)=O)=O)=O

Molecular Formula

C38H64N8O8

Molecular Weight

761.00

References & Citations

[1]Emilie Eiselt, et al. Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia. ACS Chem Neurosci. 2019 Nov 20;10 (11) :4535-4544.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

Scientific Category

Peptides

Clinical Information

No Development Reported

Isoform

NTR1; NTR2

Available Sizes

Price

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