Pemetrexed
Product Specifications
CAS Number
137281-23-3
Synonyms
LY231514
Target
Thymidylate Synthase
Applications
Apoptosis
Smiles
NC1=NC (=O) C2=C ([NH]C=C2CCC3=CC=C (C=C3) C (=O) NC (CCC (O) =O) C (O) =O) N1
Molecular Formula
C20H21N5O6
Additionnal Information
Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
Storage Conditions
3 years -20°C powder
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