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Ruxolitinib Phosphate

Product Specifications

CAS Number

1092939-17-7

Synonyms

INCB018424, INC424

Target

JAK

Applications

Angiogenesis

Smiles

C1CCC (C1) C (CC#N) N2C=C (C=N2) C3=C4C=CNC4=NC=N3.OP (=O) (O) O

Molecular Formula

C17H18N6.H3O4P

Additionnal Information

Ruxolitinib Phosphate (INCB018424, INC424) is the phosphate salt form of Ruxolitinib. Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.

Storage Conditions

2 years -80 in solvent

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