Tacrolimus (FK506)
Product Specifications
CAS Number
104987-11-3
Synonyms
FR900506, Fujimycin
Target
Phosphatase
Applications
Metabolism
Smiles
CC1CC (C2C (CC (C (O2) (C (=O) C (=O) N3CCCCC3C (=O) OC (C (C (CC (=O) C (C=C (C1) C) CC=C) O) C) C (=CC4CCC (C (C4) OC) O) C) O) C) OC) OC
Molecular Formula
C44H69NO12
Additionnal Information
Tacrolimus (FK506) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.
Storage Conditions
2 years -80 in solvent
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