STX-721
Product Specifications
UNSPSC Description
STX-721 is a mutant-selective inhibitor of EGFR and HER2 Exon 20 insertion (ex20ins) mutants[1].
Target Antigen
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/stx-721.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CCC[C@]1(C)C#CC2=C(C=CN=C2)C3=C(C4=C(N3)CCNC4=O)NC5=CC=CC(Cl)=C5OC)/C=C/CN(C)C
Molecular Weight
587.11
References & Citations
[1]R. Pagliarini, et al. Identification of STX-721, an EGFR exon 20 mutant inhibitor with superior selectivity and a potential best-in-class profile. EJC. 2023.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157229/STX-721-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157229/STX-721-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
2765525-82-2
Available Sizes
Curated Selection
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