Ixazomib Citrate (MLN9708)
Product Specifications
CAS Number
1239908-20-3
Target
Proteasome
Applications
Proteases
Smiles
CC (C) CC (NC (=O) CNC (=O) C1=C (Cl) C=CC (=C1) Cl) B2OC (=O) C (CC (O) =O) (CC (O) =O) O2
Molecular Formula
C20H23BCl2N2O9
Additionnal Information
Ixazomib Citrate (MLN9708) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ixazomib (MLN2238) also inhibits caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50 of 31 nM and 3500 nM, respectively.
Storage Conditions
3 years -20°C powder
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