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Cabozantinib malate

Product Specifications

CAS Number

1140909-48-3

Synonyms

XL184

Target

Axl

Applications

Protein Tyrosine Kinase

Smiles

COC1=CC2=C (C=CN=C2C=C1OC) OC3=CC=C (C=C3) NC (=O) C4 (CC4) C (=O) NC5=CC=C (C=C5) F.C (C (C (=O) O) O) C (=O) O

Molecular Formula

C28H24FN3O5.C4H6O5

Additionnal Information

Cabozantinib malate (XL184) is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret (c-Ret), Kit (c-Kit), Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib malate (XL184) induces apoptosis.

Storage Conditions

2 years -80 in solvent

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