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Harmine hydrochloride

Product Specifications

CAS Number

343-27-1

Synonyms

Telepathine hydrochloride

Target

DYRK

Applications

Protein Tyrosine Kinase

Smiles

CC1=NC=CC2=C1NC3=C2C=CC (=C3) OC.Cl

Molecular Formula

C13H12N2O.HCl

Additionnal Information

Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs) . Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.

Storage Conditions

2 years -80 in solvent

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