Harmine hydrochloride
Product Specifications
CAS Number
343-27-1
Synonyms
Telepathine hydrochloride
Target
DYRK
Applications
Protein Tyrosine Kinase
Smiles
CC1=NC=CC2=C1NC3=C2C=CC (=C3) OC.Cl
Molecular Formula
C13H12N2O.HCl
Additionnal Information
Harmine (Telepathine), a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. Harmine also inhibits monoamine oxidases (MAOs), PPARγ and cdc-like kinases (CLKs) . Harmine inhibits 5-HT2A serotonin receptor with Ki of 397 nM.
Storage Conditions
2 years -80 in solvent
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