Dehydrocostus Lactone
Product Specifications
CAS Number
477-43-0
Target
IκB/IKK
Applications
NF-κB
Smiles
C=C1CCC2C (C3C1CCC3=C) OC (=O) C2=C
Molecular Formula
C15H18O2
Additionnal Information
Dehydrocostus lactone (DHE), a natural sesquiterpene lactone, inhibits IKKβ activity, IκBα phosphorylation and degradation, coactivators p300 recruitments and p50/p65 NF-κB nuclear translocation, and their DNA binding activity on COX-2 promoter. It has anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.
Storage Conditions
2 years -80 in solvent
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