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Triptolide

Product Specifications

CAS Number

38748-32-2

Synonyms

PG490, NSC 163062

Target

NF-κB

Applications

NF-κB

Molecular Formula

C20H24O6

Additionnal Information

Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii. It functions as a NF-κB inhibitor with dual actions by disruption of p65/CBP interaction and by reduction of p65 protein. Triptolide (PG490) abrogates the transactivation function of heat shock transcription factor 1 (HSF1) . Triptolide inhibits MDM2 and induces apoptosis through a p53-independent pathway.

Storage Conditions

2 years -80 in solvent

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