SIS3
Product Specifications
CAS Number
1009104-85-1
Target
TGF-beta/Smad
Applications
TGF-beta/Smad
Smiles
COC1=CC2=C (CN (CC2) C (=O) \C=C\C3=C ([N] (C) C4=NC=CC=C34) C5=CC=CC=C5) C=C1OC
Molecular Formula
C28H27N3O3
Additionnal Information
SIS3 is a cell-permeable inhibitor of Smad3 that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. SIS3 reduces TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.
Storage Conditions
3 years -20°C powder
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