Resibufogenin
Product Specifications
CAS Number
465-39-4
Synonyms
Bufogenin, Recibufogenin
Target
RIP kinase
Applications
Apoptosis
Smiles
CC12CCC (O) CC1CCC3C2CCC4 (C) C (CC5OC345) C6=COC (=O) C=C6
Molecular Formula
C24H32O4
Additionnal Information
Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin protein expression.
Storage Conditions
3 years -20°C powder
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