Resibufogenin
Product Specifications
CAS Number
465-39-4
Synonyms
Bufogenin, Recibufogenin
Target
RIP kinase
Applications
Apoptosis
Smiles
CC12CCC (O) CC1CCC3C2CCC4 (C) C (CC5OC345) C6=COC (=O) C=C6
Molecular Formula
C24H32O4
Additionnal Information
Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. Resibufogenin exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Resibufogenin increases Bax/Bcl-2 expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin protein expression.
Storage Conditions
3 years -20°C powder
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
219240-01 20 µL
SMYD2 (SET and MYND Domain Containing 2, KMT3C, HSKM-B, ZMYND14) discontinued
Sign In for Pricing
View Details 219240-02 100 µL
SMYD2 (SET and MYND Domain Containing 2, KMT3C, HSKM-B, ZMYND14) discontinued
Sign In for Pricing
View Details 170487 50 µg
FPR1 (FPR1, FPR-1, FMet-Leu-Phe Receptor, FMLP, Formyl Peptide Receptor 1, FPR, N-formyl Peptide Receptor, FMLP Receptor, Fpr Receptor, N-formyl Peptide Receptor 1) discontinued
Sign In for Pricing
View Details 