Cinobufagin
Product Specifications
CAS Number
470-37-1
Synonyms
Cinobufagine
Target
ATM/ATR
Applications
PI3K/Akt/mTOR
Smiles
CC (=O) OC1C2OC23C4CCC5CC (O) CCC5 (C) C4CCC3 (C) C1C6=COC (=O) C=C6
Molecular Formula
C26H34O6
Additionnal Information
Cinobufagin (Cinobufagine), an active ingredient of Venenum Bufonis, inhibits tumor development. Cinobufagin increases ATM and Chk2 and decreases CDC25C, CDK1, and cyclin B. Cinobufagin inhibits PI3K, AKT and Bcl-2 while increases levels of cleaved caspase-9 and caspase-3. Thus, Cinobufagin induces cell cycle arrest at the G2/M phase and apoptosis.
Storage Conditions
3 years -20°C powder
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