Purmorphamine
Product Specifications
CAS Number
483367-10-8
Synonyms
Shh Signaling Antagonist VI
Target
Autophagy
Applications
Autophagy
Smiles
C1CCC (CC1) N2C=NC3=C (N=C (N=C32) OC4=CC=CC5=CC=CC=C54) NC6=CC=C (C=C6) N7CCOCC7
Molecular Formula
C31H32N6O2
Additionnal Information
Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM in HEK293T cell and also is an inducer of osteoblast differentiation with EC50 of 1 μM. Purmorphamine can reduce both basal and induced autophagy.
Storage Conditions
2 years -80 in solvent
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