Ensartinib dihydrochloride
Product Specifications
CAS Number
2137030-98-7
Synonyms
X-396 dihydrochloride
Target
ALK
Applications
Protein Tyrosine Kinase
Smiles
CC1CN (CC (N1) C) C (=O) C2=CC=C (C=C2) NC (=O) C3=NN=C (C (=C3) OC (C) C4=C (C=CC (=C4Cl) F) Cl) N.Cl.Cl
Molecular Formula
C26H29Cl4FN6O3
Additionnal Information
Ensartinib dihydrochloride is a potent new-generation ALK inhibitor with high activity against a broad range of known crizotinib-resistant ALK mutations and CNS metastases. It potently inhibits both wild-type ALK and ALK variants (F1174, C1156Y, L1196M, S1206R, T1151, and G1202R mutants) with in vitro IC50s of <4 nM.
Storage Conditions
3 years -20°C powder
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