Baricitinib
Product Specifications
CAS Number
1187594-09-7
Synonyms
INCB028050, LY3009104
Target
JAK
Applications
Angiogenesis
Smiles
CCS (=O) (=O) N1CC (C1) (CC#N) N2C=C (C=N2) C3=C4C=CNC4=NC=N3
Molecular Formula
C16H17N7O2S
Additionnal Information
Baricitinib is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM in cell-free assays, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Baricitinib is found to reduce or interrupt the passage of the virus into target cells and is used in the treatment research for COVID-19. Phase 3.
Storage Conditions
2 years -80 in solvent
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