Torin 2
Product Specifications
CAS Number
1223001-51-1
Target
ATM/ATR
Applications
PI3K/Akt/mTOR
Smiles
C1=CC (=CC (=C1) N2C (=O) C=CC3=CN=C4C=CC (=CC4=C32) C5=CN=C (C=C5) N) C (F) (F) F
Molecular Formula
C24H15F3N4O
Additionnal Information
Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM in p53−/− MEFs cell line; 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties. Inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM, in PC3 cell lines respectively. Torin 2 decreases cell viability and induces autophagy and apoptosis.
Storage Conditions
2 years -80 in solvent
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