(R) - (-) -Gossypol (AT-101) acetic acid
Product Specifications
CAS Number
866541-93-7
Target
Bcl-2
Applications
Apoptosis
Smiles
CC1=CC2=C (C (=C (C (=C2C (C) C) O) O) C=O) C (=C1C3=C (C4=C (C=C3C) C (=C (C (=C4C=O) O) O) C (C) C) O) O.CC (=O) O
Molecular Formula
C30H30O8.C2H4O2
Additionnal Information
(R) - (-) -Gossypol (AT-101) acetic acid, the R- (-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.
Storage Conditions
2 years -80 in solvent
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