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Sapanisertib (MLN0128)

Product Specifications

CAS Number

1224844-38-5

Synonyms

INK 128, TAK-228

Target

MTOR

Applications

PI3K/Akt/mTOR

Smiles

CC (C) N1C2=NC=NC (=C2C (=N1) C3=CC4=C (C=C3) OC (=N4) N) N

Molecular Formula

C15H15N7O

Additionnal Information

Sapanisertib (MLN0128, INK 128, TAK-228) is a potent and selective mTOR inhibitor with IC50 of 1 nM in cell-free assays; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin) . Phase 1.

Storage Conditions

2 years -80 in solvent

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