Tofacitinib
Product Specifications
CAS Number
477600-75-2
Synonyms
CP-690550, Tasocitinib
Target
JAK
Applications
Angiogenesis
Smiles
CC1CCN (CC1N (C) C2=NC=NC3=C2C=CN3) C (=O) CC#N
Molecular Formula
C16H20N6O
Additionnal Information
Tofacitinib is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1. Tofacitinib inhibits the expression of antiapoptotic BCL-A1 and BCL-XL in human plasmacytoid dendritic cells (PDC) and induced PDC apoptosis.
Storage Conditions
2 years -80 in solvent
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
262363-01 100 mg
Trans 1-Benzyl-4- (4-fluorophenyl) -3-piperidinemethanol
Sign In for Pricing
View Details 262363-02 250 mg
Trans 1-Benzyl-4- (4-fluorophenyl) -3-piperidinemethanol
Sign In for Pricing
View Details 262363-03 500 mg
Trans 1-Benzyl-4- (4-fluorophenyl) -3-piperidinemethanol
Sign In for Pricing
View Details