PF-5274857
Product Specifications
CAS Number
1373615-35-0
Target
Hedgehog/Smoothened
Applications
Stem Cells & Wnt
Smiles
CC1=CC (=C (N=C1) C2=CC (=NC=C2Cl) N3CCN (CC3) C (=O) CCS (=O) (=O) C) C
Molecular Formula
C20H25ClN4O3S
Additionnal Information
PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier.
Storage Conditions
2 years -80 in solvent
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