Xevinapant (AT406)
Product Specifications
CAS Number
1071992-99-8
Synonyms
ARRY-334543, Debio1143, SM-406
Target
E3 Ligase
Applications
Ubiquitin
Smiles
CC (C) CC (=O) N1CCC2CCC (N2C (=O) C (C1) NC (=O) C (C) NC) C (=O) NC (C3=CC=CC=C3) C4=CC=CC=C4
Molecular Formula
C32H43N5O4
Additionnal Information
Xevinapant (AT406, ARRY-334543, Debio1143, SM-406) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1.
Storage Conditions
2 years -80 in solvent
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