Milciclib
Product Specifications
CAS Number
802539-81-7
Synonyms
PHA-848125
Target
CDK
Applications
Cell Cycle
Smiles
CC1 (CC2=CN=C (N=C2C3=C1C (=NN3C) C (=O) NC) NC4=CC=C (C=C4) N5CCN (CC5) C) C
Molecular Formula
C25H32N8O
Additionnal Information
Milciclib is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4, 5, and 7, it's also an inhibitor of TRKA with IC50 of 53nM. Milciclib (PHA-848125) induces cell death through autophagy. Phase 2.
Storage Conditions
2 years -80 in solvent
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