AMG-458

913376-83-7

C-Met

Protein Tyrosine Kinase

CC1=C (C (=O) N (N1CC (C) (C) O) C2=CC=CC=C2) C (=O) NC3=NC=C (C=C3) OC4=C5C=CC (=CC5=NC=C4) OC

C30H29N5O5

AMG 458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.

2 years -80 in solvent