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AZ 628

Product Specifications

CAS Number

878739-06-1

Target

Raf

Applications

MAPK

Smiles

CC1=C (C=C (C=C1) NC (=O) C2=CC (=CC=C2) C (C) (C) C#N) NC3=CC4=C (C=C3) N=CN (C4=O) C

Molecular Formula

C27H25N5O2

Additionnal Information

AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM in cell-free assays, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc. AZ628 induces apoptosis.

Storage Conditions

2 years -80 in solvent

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