PHA-767491 HCl
Product Specifications
CAS Number
942425-68-5
Synonyms
CAY10572, NMS 1116354
Target
CDK
Applications
Cell Cycle
Smiles
C1CNC (=O) C2=C1NC (=C2) C3=CC=NC=C3.Cl
Molecular Formula
C12H11N3O.HCl
Additionnal Information
PHA-767491 (CAY10572, NMS 1116354) HCl is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM in cell-free assays, respectively.It displays ~20-fold selectivity against CDK1/2 and GSK3-β, 50-fold selectivity against MK2 and CDK5, 100-fold selectivity against PLK1 and CHK2.
Storage Conditions
2 years -80 in solvent
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