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AMG-900

Product Specifications

CAS Number

945595-80-2

Target

Aurora Kinase

Applications

Cell Cycle

Smiles

CC1=CSC (=C1) C2=NN=C (C3=CC=CC=C32) NC4=CC=C (C=C4) OC5=C (C=CC=N5) C6=NC (=NC=C6) N

Molecular Formula

C28H21N7OS

Additionnal Information

AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1.

Storage Conditions

2 years -80 in solvent

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