(R) - (-) -α-Methylhistamine (dihydrobromide)

(R) - (-) -α-Methylhistamine dihydrobromide is a potent, selective and brain-penetrant agonist of H3 histamine receptor, with a Kd of 50.3 nM[1][2]. (R) - (-) -α-Methylhistamine dihydrobromide can enhance memory retention, attenuates memory impairment in rats[3][4][5].

Product Specifications

CAS Number

[868698-49-1]

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/r-minus-α-methylhistamine-dihydrobromide.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

C[C@@H](N)CC1=CN=CN1.Br.Br

Molecular Formula

C6H13Br2N3

Molecular Weight

287.00

References & Citations

[1]Arrang JM, et al. Highly potent and selective ligands for histamine H3-receptors. Nature. 1987 May 14-20;327 (6118) :117-23.|[2]Mohammad Shahid, et al. Histamine, Histamine Receptors, and their Role in Immunomodulation: An Updated Systematic Review. The Open Immunology Journal, 2009, 2, 9-41.|[3]Oishi R, et al. Effects of the histamine H3-agonist (R) -alpha-methylhistamine and the antagonist thioperamideon histamine metabolism in the mouse and rat brain. J Neurochem. 1989 May;52 (5) :1388-92.|[4]Yamasaki S, et al. The disposition of (R) -alpha-methylhistamine, a histamine H3-receptor agonist, in rats. J Pharm Pharmacol. 1994 May;46 (5) :371-4.|[5]Li WW, et al. (R) -alpha-methylhistamine suppresses inhibitory neurotransmission in hippocampal CA1 pyramidal neurons counteracting propofol-induced amnesia in rats. CNS Neurosci Ther. 2014 Sep;20 (9) :851-9.