Flavopiridol (Alvocidib) HCl
Product Specifications
CAS Number
131740-09-5
Synonyms
NSC 649890, L86-8275, HMR-1275, DSP-2033
Target
CDK
Applications
Cell Cycle
Smiles
CN1CCC (C (C1) O) C2=C (C=C (C3=C2OC (=CC3=O) C4=CC=CC=C4Cl) O) O.Cl
Molecular Formula
C21H20ClNO5.HCl
Additionnal Information
Flavopiridol (Alvocidib) HCl competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol HCl induces autophagy and ER stress. Flavopiridol HCl blocks HIV-1 replication. Phase 1/2.
Storage Conditions
2 years -80 in solvent
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