WYE-687
Product Specifications
CAS Number
1062161-90-3
Target
MTOR
Applications
PI3K/Akt/mTOR
Smiles
COC (=O) NC1=CC=C (C=C1) C2=NC3=C (C=NN3C4CCN (CC4) CC5=CN=CC=C5) C (=N2) N6CCOCC6
Molecular Formula
C28H32N8O3
Additionnal Information
WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K (T389) and mTORC2/P-AKT (S473) but no effect observed on P-AKT (T308) . Selectivity for mTOR is greater than PI3Kα (>100-fold) and PI3Kγ (>500-fold) .
Storage Conditions
2 years -80 in solvent
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