Omipalisib (GSK2126458)
Product Specifications
CAS Number
1086062-66-9
Synonyms
GSK458
Target
MTOR
Applications
PI3K/Akt/mTOR
Smiles
COC1=C (C=C (C=N1) C2=CC3=C (C=CN=C3C=C2) C4=CN=NC=C4) NS (=O) (=O) C5=C (C=C (C=C5) F) F
Molecular Formula
C25H17F2N5O3S
Additionnal Information
Omipalisib (GSK2126458, GSK458) is a highly selective and potent inhibitor of p110α/β/δ/γ, mTORC1/2 with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM in cell-free assays, respectively. Omipalisib induces autophagy. Phase 1.
Storage Conditions
2 years -80 in solvent
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