RN-1734
Product Specifications
CAS Number
946387-07-1
Synonyms
TRPV4 Antagonist I
Target
TRP Channel
Applications
Neuronal Signaling
Smiles
CC (C) NCCN (C (C) C) S (=O) (=O) C1=C (C=C (C=C1) Cl) Cl
Molecular Formula
C14H22Cl2N2O2S
Additionnal Information
RN-1734 (TRPV4 Antagonist I) is a selective transient receptor potential vanilloid 4 (TRPV4) antagonist with IC50 of 2.3 μM, 5.9 μM and 3.2 μM for hTRPV4, mTRPV4 and rTRPV4, respectively. RN-1734 alleviates demyelination and inhibits glial activation and the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells.
Storage Conditions
3 years -20°C powder
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