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Rebastinib (DCC-2036)

Product Specifications

CAS Number

1020172-07-9

Target

Bcr-Abl

Applications

Protein Tyrosine Kinase

Smiles

CC (C) (C) C1=NN (C (=C1) NC (=O) NC2=C (C=C (C=C2) OC3=CC (=NC=C3) C (=O) NC) F) C4=CC5=C (C=C4) N=CC=C5

Molecular Formula

C30H28FN7O3

Additionnal Information

Rebastinib (DCC-2036) is a conformational control Bcr-Abl inhibitor for Abl1 (WT) and Abl1 (T315I) with IC50 of 0.8 nM and 4 nM, also inhibits SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2, and low activity to seen towards c-Kit. Phase 1.

Storage Conditions

2 years -80 in solvent

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