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GSK256066

Product Specifications

CAS Number

801312-28-7

Target

PDE

Applications

Metabolism

Smiles

CC1=CC (=CC2=C (C (=CN=C12) C (=O) N) NC3=CC (=CC=C3) OC) S (=O) (=O) C4=CC=CC (=C4) C (=O) N (C) C

Molecular Formula

C27H26N4O5S

Additionnal Information

GSK256066 is a selective PDE4B (equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.Phase 2.

Storage Conditions

2 years -80 in solvent

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