Gambogic Acid
Product Specifications
CAS Number
2752-65-0
Synonyms
Guttatic Acid, Guttic Acid, Beta-Guttiferrin
Target
Bcl-2
Applications
Apoptosis
Smiles
CC (=CCCC1 (C=CC2=C (C3=C (C (=C2O1) CC=C (C) C) OC45C6CC (C=C4C3=O) C (=O) C5 (OC6 (C) C) CC=C (C) C (=O) O) O) C) C
Molecular Formula
C38H44O8
Additionnal Information
Gambogic Acid (Guttatic Acid, Guttic Acid, Beta-Guttiferrin) activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.
Storage Conditions
2 years -80 in solvent
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