HFSH-β- (33-53) (TFA)
HFSH-β- (33-53) TFA, a thiol-containing peptide which corresponds to a second FSH receptor-binding domain, is a FSHR (follicle-stimulating hormone receptor) antagonist. hFSH-β- (33-53) TFA inhibits binding of FSH to receptor and is a partial agonist of estradiol synthesis in Sertoli cells[1][2][3].
Product Specifications
UNSPSC
12352209
Target
Estrogen Receptor/ERR
Type
Peptides
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hfsh-β-33-53-tfa.html
Purity
99.16
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H]1N(CCC1)C([C@H](CC(O)=O)NC([C@H](CCCCN)NC([C@@H](NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H]([C@H](O)C)NC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)=O)=O)=O)=O)CC3=CC=C(C=C3)O)=O)=O)=O)N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N4[C@@H](CCC4)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CS)C(N[C@@H]([C@H](O)C)C(N[C@H](C(O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
Molecular Formula
C115H183N31O32S.xC2HF3O2
Molecular Weight
2543.94 (free acid)
References & Citations
[1]Grasso P, et al. A synthetic peptide corresponding to hFSH-beta- (81-95) has thioredoxin-like activity. Mol Cell Endocrinol. 1991;78 (3) :163-170. |[2]Xu Y, et al. Pilot study of a novel (18) F-labeled FSHR probe for tumor imaging. Mol Imaging Biol. 2014;16 (4) :578-585. |[3]Santa-Coloma TA, et al. Serine analogues of hFSH-beta- (33-53) and hFSH-beta- (81-95) inhibit hFSH binding to receptor. Biochem Biophys Res Commun. 1992;184 (3) :1273-1279.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
