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HFSH-β- (33-53) (TFA)

HFSH-β- (33-53) TFA, a thiol-containing peptide which corresponds to a second FSH receptor-binding domain, is a FSHR (follicle-stimulating hormone receptor) antagonist. hFSH-β- (33-53) TFA inhibits binding of FSH to receptor and is a partial agonist of estradiol synthesis in Sertoli cells[1][2][3].

Product Specifications

UNSPSC

12352209

Target

Estrogen Receptor/ERR

Type

Peptides

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hfsh-β-33-53-tfa.html

Purity

99.16

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H]1N(CCC1)C([C@H](CC(O)=O)NC([C@H](CCCCN)NC([C@@H](NC([C@H](C(C)C)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H]([C@H](O)C)NC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)=O)=O)=O)=O)CC3=CC=C(C=C3)O)=O)=O)=O)N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N4[C@@H](CCC4)C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CS)C(N[C@@H]([C@H](O)C)C(N[C@H](C(O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O

Molecular Formula

C115H183N31O32S.xC2HF3O2

Molecular Weight

2543.94 (free acid)

References & Citations

[1]Grasso P, et al. A synthetic peptide corresponding to hFSH-beta- (81-95) has thioredoxin-like activity. Mol Cell Endocrinol. 1991;78 (3) :163-170. |[2]Xu Y, et al. Pilot study of a novel (18) F-labeled FSHR probe for tumor imaging. Mol Imaging Biol. 2014;16 (4) :578-585. |[3]Santa-Coloma TA, et al. Serine analogues of hFSH-beta- (33-53) and hFSH-beta- (81-95) inhibit hFSH binding to receptor. Biochem Biophys Res Commun. 1992;184 (3) :1273-1279.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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