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Silmitasertib (CX-4945)

Product Specifications

CAS Number

1009820-21-6

Target

Casein Kinase

Applications

Cell Cycle

Smiles

C1=CC (=CC (=C1) Cl) NC2=NC3=C (C=CC (=C3) C (=O) O) C4=C2C=CN=C4

Molecular Formula

C19H12ClN3O2

Additionnal Information

Silmitasertib (CX-4945) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay) . Silmitasertib induces autophagy and promotes apoptosis. Phase 1/2.

Storage Conditions

2 years -80 in solvent

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