Volasertib
Product Specifications
CAS Number
755038-65-4
Synonyms
BI 6727
Target
PLK
Applications
Cell Cycle
Smiles
CCC1C (=O) N (C2=CN=C (N=C2N1C (C) C) NC3=C (C=C (C=C3) C (=O) NC4CCC (CC4) N5CCN (CC5) CC6CC6) OC) C
Molecular Formula
C34H50N8O3
Additionnal Information
Volasertib is a highly potent Plk1 inhibitor with IC50 of 0.87 nM in a cell-free assay. It shows 6- and 65-fold greater selectivity against Plk2 and Plk3. Volasertib induces cell cycle arrest and apoptosis in various cancer cells. Phase 3.
Storage Conditions
2 years -80 in solvent
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