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Momelotinib (CYT387)

Product Specifications

CAS Number

1056634-68-4

Synonyms

LM-1149 , CYT11387

Target

JAK

Applications

Angiogenesis

Smiles

C1COCCN1C2=CC=C (C=C2) NC3=NC=CC (=N3) C4=CC=C (C=C4) C (=O) NCC#N

Molecular Formula

C23H22N6O2

Additionnal Information

Momelotinib (CYT387, LM-1149 , CYT11387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Momelotinib (CYT387) induces apoptosis and autophagy. Phase 3.

Storage Conditions

3 years -20°C (in the dark) powder

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