AMG-47a
Product Specifications
CAS Number
882663-88-9
Target
Src
Applications
Protein Tyrosine Kinase
Smiles
CC1=C (C=C (C=C1) C (=O) NC2=CC=CC (=C2) C (F) (F) F) C3=CC4=CN=C (N=C4C=C3) NCCN5CCOCC5
Molecular Formula
C29H28F3N5O2
Additionnal Information
AMG-47a is a potent, nonselective inhibitor of Lck kinase with IC50 of 3.4 uM and it also inhibits T cell proliferation. AMG-47a exhibit anti-inflammatory activity (ED50) of 11 mg/kg in the anti-CD3-induced production of interleukin-2 (IL-2) in mice.
Storage Conditions
3 years -20°C powder
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