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Infigratinib (BGJ398)

Product Specifications

CAS Number

872511-34-7

Synonyms

NVP-BGJ398

Target

FGFR

Applications

Protein Tyrosine Kinase

Smiles

CCN1CCN (CC1) C2=CC=C (C=C2) NC3=CC (=NC=N3) N (C) C (=O) NC4=C (C (=CC (=C4Cl) OC) OC) Cl

Molecular Formula

C26H31Cl2N7O3

Additionnal Information

Infigratinib (BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM in cell-free assays, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Phase 2.

Storage Conditions

2 years -80 in solvent

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